V

VARGIU L.

Last name: VARGIU L.

2000 (v1)

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Disoxaril-related 3-(diethylamino]-5-phenylisoxazoles

MAZZEI, MAURO DONDERO R LEDDA B

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Uploaded on: December 5, 2022
2003 (v1)

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Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives

RANISE, ANGELO SPALLAROSSA, ANDREA SCHENONE, SILVIA

A novel series of potent, selective HIV-1 N-acylthiocarbamate (ATC) nonnucleoside reverse transcriptase inhibitors (NNRTIs) is described. The title compds. were synthesized through a highly convergent, one-pot procedure. In cell-based assays, the lead compd. (I) prevented the HIV-1 multiplication with an EC50 of 8 μM. The lead optimization...

Uploaded on: April 14, 2023
2001 (v1)

Publication

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Synthesis and anti-HIV-1 activity of thiocarbamates, isosteres of PETT derivatives

RANISE, ANGELO SPALLAROSSA, ANDREA BRUNO, OLGA

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Uploaded on: March 31, 2023