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2012 (v1)PublicationUploaded on: April 14, 2023
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2000 (v1)Publication
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2001 (v1)Publication
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1993 (v1)Publication
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Uploaded on: December 5, 2022 -
2005 (v1)Publication
Sex hormones seem to modulate the immune/inflammatory responses by different mechanisms in female and male rheumatoid arthritis patients. The effects of 17β-oestradiol and of testosterone were tested on the cultured human monocytic/ macrophage cell line (THP-1) activated with IFN-γ in order to investigate their role in cell proliferation and...
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2006 (v1)Publication
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2014 (v1)Publication
Mild hyperuricemia has been linked to the development and progression of tubulointerstitial renal damage. However the mechanisms by which uric acid may cause these effects are poorly explored. We investigated the effect of uric acid on apoptosis and the underlying mechanisms in a human proximal tubule cell line (HK-2). Increased uric acid...
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1998 (v1)Publication
Because some of the clinical symptoms related to rheumatoid arthritis (RA) synovitis, such as joint morning stiffness and gelling, might be related to the effects exerted by the diurnal rhythmicity of the neurohormone melatonin (MLT) on synovial immune cell activation, we decided to evaluate the influence of MLT on the production of IL-12 and...
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2003 (v1)Publication
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2012 (v1)Publication
Progressive chronic kidney disease (CKD) is common in lysinuric protein intolerance (LPI), a primary inherited aminoaciduria characterized by massive Lysine excretion in urine. However, by which mechanisms Lysine may cause kidney damage to tubule cells is still not understood. This study determined whether Lysine overloading of human proximal...
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2002 (v1)Publication
abstract
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2011 (v1)Publication
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2010 (v1)Publication
To investigate the effects of 17beta-estradiol (E2) on extracellular matrix (ECM) protein synthesis (collagen type I, fibronectin, and laminin) using cultures of normal and scleroderma (SSc) skin fibroblasts. Primary fibroblasts cultures, obtained from skin biopsies of six female voluntary subjects and three female SSc patients, were treated...
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2012 (v1)Publication
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1999 (v1)Publication
Il metotrexate (MTX) è in grado di eservitare un'azione antiproliferativa ed antiinfiammatoria a livello del tessuto sinoviale. Scopo dello studio è stato quello di valutare la dose-dipendenza di entrambi gli effetti su cultire di macrofagi (Mf) sinoviali ed eentuali effetti dell'assiciazione con ormoni gonadici.
Uploaded on: March 31, 2023 -
2006 (v1)Publication
Background: Polymyalgia rheumatica (PMR) may create some difficulties in the differential diagnosis of elderly-onset rheumatoid arthritis (EORA) and of EORA with PMR-like onset (EORA/PMR). Aim: To investigate possible differences between three groups of patients, with regard to serum levels of inflammatory cytokines and steroidal hormones at...
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2003 (v1)Publication
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2009 (v1)Publication
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Uploaded on: March 31, 2023 -
2006 (v1)Publication
Whenever serum estrogen concentrations are normal in rheumatoid arthritis (RA) patients, lower androgen concentrations (i.e., testosterone, androstenedione, and dehydroepiandrosterone sulfate [DHEAS]) are detected in the serum as well as in the synovial fluid of male and female RA patients. The presence in the RA synovial fluid of a significant...
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2001 (v1)Publication
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Uploaded on: March 31, 2023 -
1989 (v1)Publication
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Uploaded on: March 31, 2023