VACHER , Pierre

We investigate the deformation localization at brittle-ductile transition in axisymmetric compression tests of rock analogue material GRAM1 made of bonded rigid particles. This transition in rocks (as well as in GRAM1) is recognized by the formation of a network of conjugate deformation localization bands in the postmortem rock samples and by a...

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Transmembrane CD95L (Fas ligand) can be cleaved to release a promigratory soluble ligand, cl-CD95L, which can contribute to chronic inflammation and cancer cell dissemination. The motility signaling pathway elicited by cl-CD95L remains poorly defined. Here, we show that in the presence of cl-CD95L, CD95 activates the Akt and RhoA signaling...

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Patients affected by chronic inflammatory disorders display high amounts of soluble CD95L. This homotrimeric ligand arises from the cleavage by metalloproteases of its membrane-bound counterpart, a strong apoptotic inducer. In contrast, the naturally processed CD95L is viewed as an apoptotic antagonist competing with its membrane counterpart...