VACHIERY , Nathalie

Ehrlichia ruminantium is an obligatory intracellular bacterium that causes heartwater, a fatal disease in ruminants. Due to its intracellular nature, E. ruminantium requires a set of specific virulence factors, such as the type IV secretion system (T4SS), and outer membrane proteins (Map proteins) in order to avoid and subvert the host's immune...

The obligate intracellular pathogenic bacterium, Ehrlichia rurninantiurn, is the causal agent of heartwater, a fatal disease in ruminants transmitted by Amblyomrna ticks. So far, three strains have been attenuated by successive passages in mammalian cells. The attenuated strains have improved capacity for growth in vitro, whereas they induced...

Ehrlichia ruminantium (ER), the causative agent of heartwater on ruminants, is an obligate intracellular bacterium transmitted by ticks of the genus Amblyomma. Previous studies have shown that early stages of development may be critical for Ehrlichia pathogenicity. To gain insights into the biology of intracellular ER, we determined the...

Background Whole genome transcriptomic analysis is a powerful approach to elucidate the molecular mechanisms controlling the pathogenesis of obligate intracellular bacteria. However, the major hurdle resides in the low quantity of prokaryotic mRNAs extracted from host cells. Our model Ehrlichia ruminantium (ER), the causative agent of...

The great fragility of ecosystems supporting food production requires alternative ways of thinking regarding the scientific research, as well as a bold analysis of public policies to be implemented to feed the planet, in an environment that would become hostile to agricultural production. In order to preserve the food ecosystems essential to...

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