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VALENCIA , Concepción

Last name: VALENCIA

First name: Concepción

May 22, 2018 (v1)

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Reversible pH-sensitive chitosan-based hydrogels. Influence of dispersion composition on rheological properties and sustained drug delivery

Iglesias, N. Galbis Fuster, Elsa Valencia, Concepción

The present work deals with the synthesis of micro-structured biomaterials based on chitosan (CTS) for their applications as biocompatible carriers of drugs and bioactive compounds. Twelve dispersions were prepared by means of functional cross-linking with tricarballylic acid (TCA); they were characterized by Fourier transform infrared...

Uploaded on: December 4, 2022
February 1, 2024 (v1)

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Biodegradable double cross-linked chitosan hydrogels for drug delivery: Impact of chemistry on rheological and pharmacological performance

Iglesias Blanco, Nieves Galbis Fuster, Elsa Valencia, Concepción

This study investigates the impact of dual ionic and covalent cross-links (ion-XrL and cov-XrL) on the properties of chitosan-based (CTS) hydrogels as eco-friendly drug delivery systems (DDS) for the model drug diclofenac sodium (DCNa). Citric acid and a diiodo-trehalose derivative (ITrh) were the chosen ionic and covalent cross-linker,...

Uploaded on: February 4, 2024