2020 (v1)
Publication
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Uploaded on: March 27, 2023
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2023 (v1)Publication
Evidence supporting the extra-skeletal role of vitamin D in modulating immune responses is centred on the effects of its final metabolite, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3, also known as calcitriol), which is regarded as a true steroid hormone. 1,25(OH)2D3, the active form of vitamin D, can modulate the innate immune system in response to...
Uploaded on: February 6, 2024 -
2023 (v1)Publication
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Uploaded on: February 6, 2024 -
2023 (v1)Publication
Evidence supporting the extra-skeletal role of vitamin D in modulating immune responses is centred on the effects of its final metabolite, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3, also known as calcitriol), which is regarded as a true steroid hormone. 1,25(OH)2D3, the active form of vitamin D, can modulate the innate immune system in response to...
Uploaded on: February 6, 2024 -
2023 (v1)Publication
Systemic sclerosis (SSc) training requires knowledge of the multisystemic nature of the disease, its clinical subsets and phases, and antibodies. SSc training should also include proficiency in special skills such as the performance of modified Rodnan skin score, capillaroscopy, and the detection of tendon friction rubs. ...
Uploaded on: February 6, 2024 -
2019 (v1)Publication
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Uploaded on: April 14, 2023 -
2023 (v1)Publication
Nailfold capillaroscopy is a safe and well-established method for the assessment of structural alterations of the microcirculation. It is a crucial tool in the investigation and monitoring of patients presenting with Raynaud's phenomenon. Detection of the char- acteristic "scleroderma pattern" on capillaroscopy may indicate an underlying...
Uploaded on: February 13, 2024 -
2023 (v1)Publication
Abstract: Objective: To investigate in an unselected, systemic sclerosis (SSc) cohort if baseline laser speckle contrast analysis (LASCA) peripheral blood perfusion (PBP) measurements differ between 'early' SSc (without skin involvement, or 'limited' SSc—LSSc) and 'clinically overt' SSc (with skin involvement, limited cutaneous SSc—LcSSc and...
Uploaded on: February 13, 2024 -
2021 (v1)Publication
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Uploaded on: April 14, 2023 -
2023 (v1)Publication
Objectives: Glucocorticosteroids (GCs) are the most used anti-inflammatory and immunosuppressive drugs due to their effectiveness in managing pain and disease modification in many immune-inflammatory rheumatic diseases (IRDs). However, their use is limited because of adverse effects (AEs). Material and methods: The authors analyzed recent...
Uploaded on: February 13, 2024 -
2023 (v1)Publication
Background: Nailfold video capillaroscopy (NVC) is a simple, non-invasive diagnostic tool but studies with normal values for capillary density in healthy children are rare. Ethnic background seems to play a role in capillary density; however, this is not well substantiated yet. In this work, we set out to evaluate influence of ethnic...
Uploaded on: February 13, 2024 -
2022 (v1)Publication
Active vitamin D [1,25(OH)(2)D-3-calcitriol] is a secosteroid hormone whose receptor is expressed on all cells of the immune system. Vitamin D has a global anti-inflammatory effect and its role in the management of a SARS-CoV-2 infection has been investigated since the beginning of the COVID-19 pandemic. In this narrative review, the laboratory...
Uploaded on: February 11, 2024 -
2024 (v1)Publication
Background and Objectives: Vitamin D is a secosteroid hormone essential for calcium homeostasis and skeletal health, but established evidence highlights its significant roles also in muscle health and in the modulation of immune response. This review aims to explore the impact of impaired vitamin D status on outcomes of muscle function and...
Uploaded on: August 20, 2024 -
2020 (v1)Publication
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Uploaded on: April 14, 2023 -
2021 (v1)Publication
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Uploaded on: April 14, 2023