VANHAECKE A

Objectives: To assess whether tools to functionally examine the microcirculation, such as laser speckle contrast analysis (LASCA), are predictive of ischaemic digital trophic lesions ([i]DTL) in patients with systemic sclerosis (SSc). Methods: First, a systematic review (according to PRISMA) was conducted to identify studies describing a link...

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Objectives: Systemic sclerosis (SSc) is a rare and complex autoimmune disorder characterized by microvascular damage and progressive fibrosis which affects the skin and multiple other organs. Much of the published data concerning SSc and the eye consists of single case reports or small case studies. This systematic review aims to provide an...

Objective Pulmonary arterial hypertension (PAH) is one of the leading causes of death in systemic sclerosis (SSc). Current screening algorithms are hampered by low positive predictive values. Outcome measures that could futurely add to performance characteristics would be very welcome. Against this background, we aim to evaluate the role of...

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Objectives:A reliable tool to evaluateflow is paramount in systemic sclerosis (SSc). We describe herein on theone hand a systematic literature review on the reliability of laser speckle contrast analysis (LASCA) to measurethe peripheral blood perfusion (PBP) in SSc and perform an additional pilot study, investigating the intra- andinter-rater...

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Objective In systemic lupus erythematosus (SLE), it is necessary to obtain biomarkers that predict cardiovascular complications due to premature atherosclerosis, which is related to endothelial dysfunction. Nailfold capillary abnormalities might be a biomarker for endothelial dysfunction. In adults and children with SLE, nailfold capillary...