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VECCHIONE L

Last name: VECCHIONE L

2011 (v1)

Publication

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MEK inhibitor as a single agent and in combination with everolimus or sorafenib in a panel of colorectal cancer cell lines: implication for multitargeted approach

MARTINELLI, Erika TROIANI, Teresa MORGILLO, Floriana

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Uploaded on: April 14, 2023
2012 (v1)

Publication

Metadata-only

Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells

Troiani T Vecchione L Martinelli E

Background:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development.Methods:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell characteristics correlating...

Uploaded on: April 14, 2023