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April 9, 2021 (v1)PublicationUploaded on: March 25, 2023
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October 23, 2023 (v1)Publication
RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is...
Uploaded on: November 25, 2023 -
April 26, 2016 (v1)Publication
The Golgi complex represents a major subcellular location of protein kinase A (PKA) concentration in mammalian cells where it has been previously shown to be involved in vesicle-mediated protein transport processes. We have studied the factors that influence the interaction of PKA typeII subunits with the Golgi complex. In addition to the...
Uploaded on: December 4, 2022 -
February 17, 2020 (v1)Publication
Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to heterogeneous tumours. Low local or systemic tissue oxygen concentration has emerged as a...
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March 28, 2022 (v1)Publication
The existence of a subpopulation of undifferentiated cells with stem-like properties has been suggested in neuroblastoma tumors, but a definitive biomarker for their successful isolation is missing. Here we describe an in vitro culture system for the enrichment in undifferentiated stem-like tumor cells for subsequent functional assays. We make...
Uploaded on: December 4, 2022 -
May 16, 2022 (v1)Publication
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Uploaded on: March 25, 2023 -
April 22, 2020 (v1)Publication
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Uploaded on: March 25, 2023