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VELAGAPUDI , Srividya

Last name: VELAGAPUDI

First name: Srividya

2024 (v1)

Publication

Metadata-only

Inhibition of de novo ceramide synthesis by Sirtuin-1 improves beta-cell function and glucose metabolism in type 2 diabetes

Velagapudi, Srividya Karsai, Gergely Karsai, Maria

Background: Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular diseases (CVD). Dysregulated pro-apoptotic ceramide synthesis reduces β-cell insulin secretion, thereby promoting hyperglycemic states which may manifest as T2D. Pro-apoptotic ceramides modulate insulin sensitivity and glucose tolerance while being linked to...

Uploaded on: July 3, 2024