Acid-Sensing Ion Channels (ASIC) are trimeric excitatory ion channels activated by extracellular acidification, a phenomenom often encountered in painful pathological diseases. Several members of this family (ASIC1a, ASIC1b, ASIC2a, ASIC2b and ASIC3) can form functional ion channels expressed mainly in the nervous system. Among them, ASIC1b is...
-
July 9, 2019 (v1)PublicationUploaded on: December 4, 2022
-
August 11, 2021 (v1)Journal article
Neuronal proton-gated Acid-Sensing Ion Channels (ASICs) participate in the detection of tissue acidosis, a phenomenon often encountered in painful pathological diseases. Such conditions
Uploaded on: December 4, 2022 -
July 1, 2020 (v1)Journal article
International audience
Uploaded on: February 22, 2023 -
June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: February 22, 2023 -
July 1, 2020 (v1)Journal article
International audience
Uploaded on: February 22, 2023 -
June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: December 4, 2022 -
July 1, 2020 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
July 1, 2020 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
July 1, 2020 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
October 25, 2022 (v1)Publication
Acid-sensing ion channels (ASICs) are voltage-independent H-gated cation channels largely expressed in the nervous system of rodents and humans, and involved in pain sensing and associated pathologies. At least six isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) associate into homotrimers or heterotrimers to form functional channels with highly...
Uploaded on: March 27, 2023 -
2022 (v1)Journal article
Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) associate into homotrimers or heterotrimers to form functional channels with highly pH-dependent gating properties. This review provides an update...
Uploaded on: December 3, 2022 -
June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: February 22, 2023 -
June 2021 (v1)Journal article
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main...
Uploaded on: December 4, 2022 -
2018 (v1)Journal article
Background and purpose: Acid-sensing ion channels (ASICs) are neuronal proton sensors emerging as potential therapeutic targets in pain of the orofacial region. Amiloride, a non‐specific ASIC blocker, has been shown to exert beneficial effects in animal models of migraine and in patients. We explored the involvement of the ASIC1‐subtype in...
Uploaded on: December 4, 2022 -
September 2021 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
September 2021 (v1)Journal article
International audience
Uploaded on: February 22, 2023 -
September 2021 (v1)Journal article
International audience
Uploaded on: February 22, 2023 -
September 2021 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
September 2021 (v1)Journal article
Activation and sensitization of trigeminal ganglia (TG) sensory neurons, leading to the release of pro-inflammatory peptides such as calcitonin gene-related peptide (CGRP), are likely a key component in migraine-related headache induction. Reducing TG neuron excitability represents therefore an attractive alternative strategy to relieve...
Uploaded on: December 3, 2022 -
September 2021 (v1)Journal article
Activation and sensitization of trigeminal ganglia (TG) sensory neurons, leading to the release of pro-inflammatory peptides such as calcitonin gene-related peptide (CGRP), are likely a key component in migraine-related headache induction. Reducing TG neuron excitability represents therefore an attractive alternative strategy to relieve...
Uploaded on: December 3, 2022 -
2019 (v1)Journal article
It is often unclear why some genetic mutations to a given gene contribute to neurological disorders and others do not. For instance, two mutations have previously been found to produce a dominant negative for TRESK, a two-pore-domain K+ channel implicated in migraine: TRESK-MT, a 2-bp frameshift mutation, and TRESK-C110R. Both mutants inhibit...
Uploaded on: December 4, 2022