IMPORTANCE Radiologically isolated syndrome (RIS) represents the earliest detectable preclinical phase of multiple sclerosis (MS) punctuated by incidental magnetic resonance imaging (MRI) white matter anomalies within the central nervous system.OBJECTIVE To determine the time to onset of symptoms consistent with MS.DESIGN, SETTING, AND...
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2023 (v1)PublicationUploaded on: February 14, 2024
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2019 (v1)Publication
Background: Steps towards the development of diagnostic criteria are needed for children with the radiologically isolated syndrome to identify children at risk of clinical demyelination. Objectives: To evaluate the 2005 and 2016 MAGNIMS magnetic resonance imaging criteria for dissemination in space for multiple sclerosis, both alone and with...
Uploaded on: April 14, 2023 -
2024 (v1)Publication
Significant advancements have been achieved in delineating the progress of the Global PROMS (PROMS) Initiative. The PROMS Initiative, a collaborative endeavor by the European Charcot Foundation and the Multiple Sclerosis International Federation, strives to amplify the influence of patient input on MS care and establish a cohesive perspective...
Uploaded on: October 25, 2024 -
November 18, 2024 (v1)Journal article
BackgroundIn multiple sclerosis (MS), the measure of the loss of autonomy appears to be particularly relevant to provide adapted and personalized responses to improve the quality of care in routine clinical practice. In this context, this research aimed to develop a new patient-reported outcome measure (PROM) evaluating MS patients' autonomy,...
Uploaded on: January 13, 2025 -
July 2021 (v1)Journal articleSerum Neurofilament Levels and PML Risk in Patients With Multiple Sclerosis Treated With Natalizumab
Objectives: The study aimed to assess the potential for serum neurofilament light chain (NFL) levels to predict the risk of progressive multifocal leukoencephalopathy (PML) in natalizumab (NTZ)-treated patients with multiple sclerosis (MS) and to discriminate PML from MS relapses.Methods: NFL levels were measured with single molecule array...
Uploaded on: December 3, 2022