Dermatofibrosarcoma protuberans (DFSP) is a soft-tissue sarcoma characterized by a high risk of local infiltration. The identification of the COL1A1-PDGFB t(17;22) translocation activating the PDGF pathway led to the use of imatinib in unresectable DFSP, with a response rate of 36-80%. Pazopanib is a multitarget tyrosine kinase inhibitor...
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April 2021 (v1)Journal articleUploaded on: December 3, 2022
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February 9, 2021 (v1)Journal article
Importance: The optimal transfusion strategy in patients with acute myocardial infarction and anemia is unclear.Objective: To determine whether a restrictive transfusion strategy would be clinically noninferior to a liberal strategy.Design, setting, and participants: Open-label, noninferiority, randomized trial conducted in 35 hospitals in...
Uploaded on: April 14, 2023