V

M

VIGNES , Michel

Last name: VIGNES

First name: Michel

2016 (v1)

Journal article

Metadata-only

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid ă pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease

Baranger, Kévin Marchalant, Yannick Bonnet, Amandine E.

Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly expressed in the nervous system with emerging roles in brain pathophysiology. The implication of MT5-MMP in Alzheimer's disease (AD), notably its interplay with the amyloidogenic process, remains elusive. Accordingly, we crossed the genetically engineered 5xFAD mouse...

Uploaded on: December 4, 2022
May 28, 2024 (v1)

Publication

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Glutamate partner drives gamma-glutamyl-dipeptide effects on ionotropic glutamate receptors

Rolland, Valérie Andreu, Sandro Gizzi, Victoria

Gamma-glutamyl dipeptides are yielded by the condensation of glutamate with another amino acid on the gamma position. Their synthesis results from the hydrolysis of glutathione (GSH ; gamma-Glu-Cys-Gly) by gamma- glutamyl transferase (GGT). In fact, while g-glutamyl dipeptides have been detected in different organs and fluids of the body,...

Uploaded on: October 18, 2024