VILCHES PÉREZ , José Ignacio

The understanding of the cellular basis of osteoblastic cell-biomaterial interaction is crucial to the analysis of the mechanism of osseointegration. Cell adhesion is a complex process that is dependent on the cell types and on the surface microtopography and chemistry of the substrate. We have studied the role of microtopography in modulating...

En la actualidad se acepta que gran parte de las funciones dinámicas de las células están reguladas por señales externas procedentes del medio extracelular. El medio extracelular da lugar, por tanto, a un constructo en el cual las células se mueven, crecen, se organizan y diferencian para formar tejidos. La interacción célula-material es uno de...

Osseointegration of implants is crucial for the long-term success of oral implants. The periimplant bone formation by osteoblasts is strongly dependent on the local mechanical environment in the interface zone. Robust demands for energy are placed on osteoblasts during the adhesion process to solid surfaces, and mitochondria are capital...

The possibility of tailoring membrane surfaces with osteoconductive potential, in particular in biodegradable devices, to create modified biomaterials that stimulate osteoblast response should make them more suitable for clinical use, hopefully enhancing bone regeneration. Bioactive inorganic materials, such as silica, have been suggested to...

New biomaterials for Guided Bone Regeneration (GBR), both resorbable and non-resorbable, are being developed to stimulate bone tissue formation. Thus, the in vitro study of cell behavior towards material surface properties turns a prerequisite to assess both biocompatibility and bioactivity of any material intended to be used for clinical...

Membrana reabsorbible para regeneración ósea guiada. La invención se refiere a membranas para la regeneración ósea guiada, que comprenden un polímero biodegradable que ha sido tratado en una de sus caras con un plasma, y sobre el que se ha depositado una o más capas nanométricas de óxidos activos en una o en las dos caras. La invención...