VILLEGAS LAMA , Isabel

Los antiinflamatorios no esteroides (AINE) se encuentran entre los fármacos más consumidos en todo el mundo. Su amplia utilización está avalada por sus propiedades analgésicas, antiinflamatorias y antipiréticas. Sin embargo, el uso de estos fármacos se acompaña de efectos secundarios, que pueden aparecer hasta en el 25% de los pacientes, siendo...

No description

Introducción: El futuro inmediato de la farmacia requiere la incorporación de servicios profesionales orientados a optimizar la gestión personalizada del paciente. Objetivos del trabajo: Determinar las características de los pacientes/usuarios registrados en la base de datos de una farmacia comunitaria con el fin de detectar sus necesidades...

Ulcerative colitis is a nonspecific inflammatory disorder characterized by oxidative and nitrosative stress, leucocyte infiltration and upregulation of inflammatory mediators. Resveratrol is a polyphenolic compound found in grapes and wine, with multiple pharmacological actions, mainly anti-inflammatory, antioxidant, antitumour and...

Scope:Squalene is a polyunsaturated triterpene, which has exhibited anticancer and antioxidantactivities among others. We investigated dietary squalene supplementation effect on an acutecolitis model induced by dextran sulfate sodium (DSS) in C57BL/6 mice.Methods and results:Mice were fed from weaning with squalene at 0.02% and 0.1%. After4...

No description

Helicobacter pylori is the main pathogen responsible for gastric ulcers and a predisposing factor of stomach cancer. Although current treatment is usually successful, it requires high doses and frequent administration. An innovative mucoadhesive system (Mucolast®) loaded with amoxicillin and clarithromycin is proposed to improve the efficacy of...

The aim of this study was to develop an optimal synthetic route to obtain natural (R)-8-methylsulfinyloctyl isothiocyanate ((R)-8-OITC), present in watercress, based on the "DAG methodology" as well as to evaluate its potential antioxidant and immunomodulatory effects, exploring possible signaling pathways that could be involved in an ex vivo...

The aim of this study was to explore the immunomodulatory effects of the natural enantiomer (R)-Sulforaphane (SFN) and the possible signaling pathways involved in an ex vivo model of LPS-stimulated murine peritoneal macrophages. Furthermore, we studied the epigenetic changes induced by (R)-SFN as well as the post-translational modifications of...

Olacein (OLA), one of the main secoiridoids derived from extra virgin olive oil (EVOO), has been shown to modulate oxidative and inflammatory responses in various pathological conditions; however, its potential benefit in joint disorders such as rheumatoid arthritis (RA) is unknown. Therefore, this study was designed to evaluate the preventive...