VIRTANEN , Kirsi

Metabolites of omega-6 and omega-3 polyunsaturated fatty acids are important signaling molecules implicated in the control of adipogenesis and energy balance regulation. Some of these metabolites belonging to the group of oxylipins have been associated with non-shivering thermogenesis in mice mediated by brown or brite adipose tissue. We aimed...

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Highlights d Cold induces a change in serum metabolites that are essential to NAD + metabolism d Circulatory NAM, tryptophan, and kynurenine are linked to BAT activation during cold d NAD + biosynthesis pathways are upregulated in BAT compared with WAT d BAT NAD + biosynthesis is related to whole-body metabolic health

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Human brown adipocytes are able to burn fat and glucose and are now considered as a potential strategy to treat obesity, type 2 diabetes and metabolic disorders. Besides their thermogenic function, brown adipocytes are able to secrete adipokines. One of these is visfatin, a nicotinamide phosphoribosyltransferase involved in NAD synthesis, known...

International audience

International audience

Activation of thermogenic brown and beige adipocytes is considered as a strategy to improve metabolic control. Here, we identify GPR180 as a receptor regulating brown and beige adipocyte function and whole-body glucose homeostasis, whose expression in humans is associated with improved metabolic control. We demonstrate that GPR180 is not a GPCR...