Anthracyclines' cardiotoxicity involves an accelerated generation of reactive oxygen species. This oxidative damage has been found to accelerate the expression of hexose-6P-dehydrogenase (H6PD), that channels glucose-6-phosphate (G6P) through the pentose phosphate pathway (PPP) confined within the endoplasmic/sarcoplasmic reticulum (SR). To...
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2023 (v1)PublicationUploaded on: July 3, 2024
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2023 (v1)Publication
Simple Summary Background: Previous studies reported mitochondrial and endoplasmic reticulum (ER) redox stress in Circulating mononucleated cells (PBMCs) of patients with Hodgkin lymphoma (HL) display an oxidative damage to the endoplasmic reticulum. Here, we assessed whether the redox stress also characterizes tissues not directly involved in...
Uploaded on: February 7, 2024 -
2024 (v1)Publication
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Uploaded on: August 6, 2024 -
2024 (v1)Publication
Background: Selective deprivation of glutamine has been shown to accelerate the generation of reactive oxygen species (ROS) and to impair the activity of a specific pentose phosphate pathway (PPP) located within the endoplasmic reticulum (ER). The consequent oxidative damage suggests that glucose flux through this reticular pathway might...
Uploaded on: August 6, 2024