VOURET-CRAVIARI , V.

The proteinase-activated receptors (PAR) PAR1 and PAR2 mediate responses to thrombin and trypsin-like proteases, respectively. Both receptors are expressed on endothelial cells where they have been reported to transduce a similar set of intracellular responses. In cultured human umbilical vein endothelial cells (HUVEC), we observed a marked...

Colitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD). Binding of extracellular ATP to thepurinergic receptor P2RX7 has emerged as a critical event incontrolling intestinal inflammation, acting to limit elevation ofproinflammatory mast cells and cytokines and promote survival ofregulatory T cells (Treg) and...