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VRIENDT , Veerle De

Last name: VRIENDT

First name: Veerle De

2013 (v1)

Publication

Metadata-only

Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells

MARTINELLI, Erika TROIANI, Teresa D'Aiuto, Elena

The RAS/RAF/MEK/MAPK and the PTEN/PI3K/AKT/mTOR pathways are key regulators of proliferation and survival in human cancer cells. Selective inhibitors of different transducer molecules in these pathways have been developed as molecular targeted anti-cancer therapies. The in vitro and in vivo anti-tumor activity of pimasertib, a selective MEK 1/2...

Uploaded on: April 14, 2023