WAEBER , Christian

The sphingolipid sphingosine-1-phosphate (S1P) acts on five subtypes of G protein coupled receptors,termed S1P1 (formerly Endothelial Differentiation Gene-1, Edg-1), S1P2 (Edg-5), S1P3 (Edg-3), S1P4(Edg-6) and S1P5 (edg-8), and possibly several other "orphan" receptors, such as GPR3, GPR6 andGPR12. These receptors are coupled to different...

Sphingosine-1-phosphate (S1P) is a lipid mediator that exerts multiple cellular functions through activation of a subfamily of G-protein-coupled receptors. Although there is evidence that S1P plays a role in the developing and adult CNS, little is known about the ability of brain parenchyma to synthesize this lipid. We have therefore analyzed...