International audience
-
January 2019 (v1)Journal articleUploaded on: December 4, 2022
-
July 2004 (v1)Journal article
Several reports indicate that osteoclasts and B-lymphocytes share a common progenitor. This study focuses on the characterization of this bipotent progenitor from the bone marrow of the osteopetrotic oc/oc mouse, where the bipotent progenitor population is amplified, and of normal mice. INTRODUCTION: Osteoclasts have a myelomonocytic origin,...
Uploaded on: March 26, 2023 -
January 31, 2019 (v1)Journal article
No description
Uploaded on: December 3, 2022 -
July 2006 (v1)Journal article
OBJECTIVE: We recently identified in the mouse bone marrow a B-lymphoid/myeloid B220+ CD11b+ progenitor population. This population is accumulated in the osteopetrotic oc/oc mouse, which suggests that it could be controlled by bone marrow factors whose expression varies in this pathologic bone environment. Among the possible factors,...
Uploaded on: March 26, 2023 -
September 2004 (v1)Journal article
Infantile malignant osteopetrosis (IMO) is a rare and lethal disease characterized by an absence of bone resorption due to inactive OCLs. Affected patients display an increased bone mass and hematological defects. The osteopetrotic oc/oc mouse displays a bone phenotype similar to the one observed in IMO patients, and the same gene, Tcirg1, is...
Uploaded on: March 26, 2023 -
November 2, 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
November 23, 2011 (v1)Conference paper
International audience
Uploaded on: December 4, 2022 -
May 1, 2008 (v1)Journal article
Natural CD25(+)CD4(+) regulatory T cells (Treg) are essential for self-tolerance and for the control of T cell-mediated immune pathologies. However, the identification of Tregs in an ongoing immune response or in inflamed tissues remains elusive. Our experiments indicate that TIRC7, T cell immune response cDNA 7, a novel membrane molecule...
Uploaded on: December 4, 2022 -
December 15, 2008 (v1)Journal article
Finding that activated T cells control osteoclast (OCL) differentiation has revealed the importance of the interactions between immune and bone cells. Dendritic cells (DCs) are responsible for T-cell activation and share common precursors with OCLs. Here we show that DCs participate in bone resorption more directly than simply through T-cell...
Uploaded on: December 3, 2022 -
June 19, 2019 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
July 2011 (v1)Journal article
B-cell development is dependent on the interactions between B-cell precursors and bone marrow stromal cells, but the role of osteoclasts (OCLs) in this process remains unknown. B lymphocytopenia is a characteristic of osteopetrosis, suggesting a modulation of B lymphopoiesis by OCL activity. To address this question, we first rescued OCL...
Uploaded on: December 3, 2022 -
November 23, 2011 (v1)Conference paper
International audience
Uploaded on: December 3, 2022 -
January 25, 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
May 13, 2020 (v1)Journal article
Bone destruction relies on interactions between bone and immune cells. Boneresorbing osteoclasts (OCLs) were recently identified as innate immune cells activating T cells toward tolerance or inflammation. Thus, pathological bone destruction not only relies on increased osteoclast differentiation, but also on the presence of inflammatory OCLs...
Uploaded on: December 4, 2022 -
January 4, 2021 (v1)Publication
Increased myelopoiesis is a hallmark of many chronic inflammatory diseases. However, the mechanisms involved in the myeloid skewing of hematopoiesis upon inflammation are still incompletely understood. Here, we identify an unexpected role of bone-resorbing osteoclasts in promoting hematopoietic stem cell (HSC) proliferation and differentiation...
Uploaded on: December 4, 2022 -
September 2012 (v1)Journal article
T-cell regulation in adipose tissue provides a link between inflammation and insulin resistance. Because of alterations in adipose tissue T-cell composition in obesity, we aimed to identify the antigen-presenting cells in adipose tissue of obese mice and patients with insulin resistance. Dendritic cells (DCs) and T cells were studied in mice...
Uploaded on: December 4, 2022 -
September 1, 2012 (v1)Journal article
T-cell regulation in adipose tissue provides a link between inflammation and insulin resistance. Because of alterations in adipose tissue T-cell composition in obesity, we aimed to identify the antigen-presenting cells in adipose tissue of obese mice and patients with insulin resistance. Dendritic cells (DCs) and T cells were studied in mice...
Uploaded on: March 10, 2024 -
2023 (v1)Journal article
Bone destruction is a hallmark of chronic inflammation, and bone-resorbing osteoclasts arising under such a condition differ from steady-state ones. However, osteoclast diversity remains poorly explored. Here, we combined transcriptomic profiling, differentiation assays and in vivo analysis in mouse to decipher specific traits for inflammatory...
Uploaded on: May 6, 2023 -
January 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
January 2009 (v1)Journal article
OBJECTIVE: Osteopontin (OPN) plays an important role in the development of insulin resistance and liver complications in dietary murine models. We aimed to determine the expression pattern of OPN and its receptor CD44 in obese patients and mice according to insulin resistance and liver steatosis. RESEARCH DESIGN AND METHODS: OPN and CD44...
Uploaded on: December 3, 2022 -
January 1, 2009 (v1)Journal article
OBJECTIVE—Osteopontin (OPN) plays an important role in the development of insulin resistance and liver complications in dietary murine models. We aimed to determine the expression pattern of OPN and its receptor CD44 in obese patients and mice according to insulin resistance and liver steatosis. RESEARCH DESIGN AND METHODS—OPN and CD44...
Uploaded on: March 10, 2024 -
June 2022 (v1)Journal article
International audience
Uploaded on: February 22, 2023 -
June 2022 (v1)Journal article
International audience
Uploaded on: December 3, 2022 -
June 2022 (v1)Journal article
Highlights d Adrenal glands contain multiple macrophage populations d Macrophage sex dimorphism depends on the presence of the cortical X zone d Embryonic and monocyte-derived macrophages co-exist in adrenal glands
Uploaded on: December 4, 2022