ZAMBETTI , Gerard

Phosphodiesterases (PDEs) form a superfamily of enzymes that catalyze the hydrolysis of cyclic nucleotides adenosine 3 5-cyclic monophosphate (cAMP) and guanosine 3 5-cyclic monophosphate (cGMP) to their inactive 5 monophosphates. cAMP plays a critical role as a second messenger in endocrine tissues, and activation of cAMP signaling has been...

The steroidogenic factor 1 (SF-1) gene encodes a transcription factor playing a pivotal role in the regulation of adrenogenital development. We have recently shown that SF-1 is amplified in childhood adrenocortical tumours (ACT). This study was aimed to assess if an increase in SF-1 gene copy number was associated with increased protein levels...