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ZAMFIR , Raluca

Last name: ZAMFIR

First name: Raluca

2016 (v1)

Publication

Metadata-only

Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein

Manassero, Giusi Guglielmotto, Michela Zamfir, Raluca

The mechanistic relationship between amyloid β1-42 (Aβ1-42) and the alteration of Tau protein are debated. We investigated the effect of Aβ1-42 monomers and oligomers on Tau, using mice expressing wild-type human Tau that do not spontaneously develop Tau pathology. After intraventricular injection of Aβ1-42, mice were sacrificed after 3 h or...

Uploaded on: March 27, 2023