Z

J

ZELY , Jeremy

Last name: ZELY

First name: Jeremy

May 13, 2020 (v1)

Journal article

Metadata-only

The inhibition of eIF5A hypusination by GC7, a preconditioning protocol to prevent brain death‐induced renal injuries in a preclinical porcine kidney transplantation model

Giraud, Sebastien Kerforne, Thomas Zely, Jeremy

The eIF5A hypusination inhibitor GC7 (N1-guanyl-1,7-diaminoheptane) was shown to protect from ischemic injuries. We hypothesized that GC7 could be useful for preconditioning kidneys from donors before transplantation. Using a preclinical porcine brain death (BD) donation model, we carried out in vivo evaluation of GC7 pretreatment (3 mg/kg iv,...

Uploaded on: December 4, 2022