ZERHOUNI , Marwa

Cutaneous metastatic melanoma (CMM) and myelodysplastic syndromes (MDS) are two incurable cancers developing resistance to their reference antitumor treatments. Cells resistant to these therapies are characterized by a metabolic reprogramming which profoundly influences and promotes tumor progression. Therefore, inhibition of metabolic pathways...

A series of nucleoside analogues bearing a 1,4,5-trisubstituted-1,2,3-triazole aglycone was synthesized using a straightforward click/electrophilic addition or click/oxidative coupling tandem procedures. SAR analysis, using cell culture assays, led to the discovery of a series of compounds belonging to the 5-alkynyl-1,2,3-triazole family that...

Abstract In the search of biguanide-derived molecules against melanoma, we have discovered and developed a series of bioactive products and identified the promising new compound CRO15. This molecule exerted anti-melanoma effects on cells lines and cells isolated from patients including the ones derived from tumors resistant to BRAF inhibitors....