ZERIMECH , Sarah

Cortical Spreading Depression is a wave of neuronal depolarization that spread slowly across cerebral cortex. It generates a rapid phase of neuronal hyperactivity, followed by a slower phase of electrical silence of cortical cells. It is possible to experimentally induce CSD on several animal models, in vivo or on neocortical slices, by focal...

article dans Nice Matin page Santé relatif à la "Semaine du cerveau"

Cortical spreading depression (CSD) is a wave of transient network hyperexcitability leading to long lasting depolarization and block of firing, which initiates focally and slowly propagates in the cerebral cortex. It causes migraine aura and it has been implicated in the generation of migraine headache. Cortical excitability can be modulated...

Spreading depolarizations (SDs) are involved in migraine, epilepsy, stroke, traumatic brain injury, and subarachnoid hemorrhage. However, the cellular origin and specific differential mechanisms are not clear. Increased glutamatergic activity is thought to be the key factor for generating cortical spreading depression (CSD), a pathological...