Z
J
Last name: ZHAO
First name: Jingsi
International audience
International audience
A network dependency platform was generated to define a landscape of cancer drug mechanisms in pulmonary hypertension.
A network dependency platform was generated to define a landscape of cancer drug mechanisms in pulmonary hypertension.
Cancer therapies are being considered for treating rare noncancerous diseases like pulmonary hypertension (PH), but effective computational screening is lacking. Via transcriptomic differential dependency analyses leveraging parallels between cancer and PH, we mapped a landscape of cancer drug functions dependent upon rewiring of PH gene...
International audience
Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease driven by hypoxia inducible factor (HIF)–dependent vascular dysfunction, HIF-2α promoted expression of neighboring genes, long noncoding RNA (lncRNA) histone lysine...