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ZIZZARI AT

Last name: ZIZZARI AT

2010 (v1)

Publication

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2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

Dreassi E Zizzari AT Mori M

The main aim of this study was to enhance the soly. of pyrazolo[3,4-d]pyrimidines 1-8 able to strongly inhibit Src and Abl tyrosine kinase phosphorylation in cell-free assays and to significantly reduce leukemic and osteosarcoma cell lines growth, but characterized by very low soly. in aq. media. Their water soly. was improved between 100 and...

Uploaded on: May 11, 2023
2008 (v1)

Publication

Metadata-only

Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model.

Tuccinardi T SCHENONE, SILVIA BONDAVALLI, FRANCESCO

Sixty-eight new substituted pyrazolo[3,4-b]pyridine derivatives were synthesized and tested for enriching a library of active A1 adenosine receptor (AR) antagonists belonging to the same class. These compounds were also used as an external test set to check the reliability of a 3D QSAR model recently reported by us. To investigate the binding...

Uploaded on: May 13, 2023