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ZOCCHI , M. R.

Last name: ZOCCHI

First name: M. R.

2011 (v1)

Publication

Metadata-only

Down regulation of human natural killer cell-mediated cytolysis induced by blood transfusion: Role of transforming growth factor-β1, soluble Fas ligand, and soluble Class i human leukocyte antigen

Ghio, M. Contini, P. Negrini, S.

Abstract BACKGROUND: Human natural killer (NK) cells are thought to play a role in antiviral response and tumor immune surveillance. The molecular mechanisms of down regulation of NK-cell activity observed after red blood cell (RBC) transfusion is still undefined. STUDY DESIGN AND METHODS: Both effects of blood transfusion (ex vivo) and...

Uploaded on: March 27, 2023
2005 (v1)

Publication

Metadata-only

Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors

Poggi, A. Negrini, S. Zocchi, M. R.

Patients with paroxysmal nocturnal hemoglobinuria (PNH) have a large clonal population of blood cells deriving from hematopoietic stem cells (HSCs) deficient in glycosylphosphatidylinositol (GPI)-anchored surface molecules. A current model postulates that PNH arises through negative selection against normal HSCs exerted by autoreactive T cells,...

Uploaded on: April 14, 2023