In adult respiratory distress syndrome (ARDS), life-threatening hypoxemia may occur, dictating the need for differentiated ventilator strategies. Pronounced consolidation and/or atelectasis have been well documented in ARDS, but the contribution of regional perfusion to oxygenation has been poorly addressed. Evidence has accumulated that, in...
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2015 (v1)PublicationUploaded on: April 14, 2023
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2018 (v1)Publication
The European Medicines Agency (EMA) has advised taking HES off the market.There are numerous questions arising from this decision:First, and most importantly, do you agree?Then: Since 2013, we have already several limitations of HES (in duration, dose and indications), which have been - albeit still questionable-generally accepted. Currently,...
Uploaded on: April 14, 2023 -
2018 (v1)Publication
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Uploaded on: April 14, 2023 -
2016 (v1)Publication
Several respiratory diseases feature increased inflammatory response and catabolic activity, which are associated with glutamine depletion; thus, the benefits of exogenous glutamine administration have been evaluated in clinical trials and models of different respiratory diseases. Recent reviews and meta-analyses have focused on the effects and...
Uploaded on: April 14, 2023 -
2016 (v1)Publication
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Uploaded on: April 14, 2023 -
2017 (v1)Publication
Background: Fluid resuscitation is the cornerstone in treatment of shock, and intravenous fluid administration is the most frequent intervention in operation rooms and intensive care units (ICUs). The composition of fluids used for fluid resuscitation gained interest over the past decade, with recent focus on whether balanced solutions should...
Uploaded on: April 14, 2023 -
2016 (v1)Publication
In patients with emphysema, invasive mechanical ventilation settings should be adjusted to minimize hyperinflation while reducing respiratory effort and providing adequate gas exchange. We evaluated the impact of pressure-controlled ventilation (PCV) and pressure support ventilation (PSV) on pulmonary and diaphragmatic damage, as well as...
Uploaded on: April 14, 2023 -
2017 (v1)Publication
Lung ischemia-reperfusion injury remains a major complication after lung transplantation. Variable ventilation (VV) has been shown to improve respiratory function and reduce pulmonary histological damage compared to protective volume-controlled ventilation (VCV) in different models of lung injury induced by endotoxin, surfactant depletion by...
Uploaded on: April 14, 2023