Differentiation of germ cells into male gonocytes or female oocytes is a central event in sexual reproduction. Proliferation and differentiation of fetal germ cells depend on the sex of the embryo. In male mouse embryos, germ cell proliferation is regulated by the RNA helicase Mouse Vasa homolog gene and factors synthesized by the somatic...
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2011 (v1)Journal articleUploaded on: December 3, 2022
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May 26, 2020 (v1)Journal article
In mammals, testicular differentiation is initiated by transcription factors SRY and SOX9 in XY gonads, and ovarian differentiation involves R-spondin1 (RSPO1) mediated activation of WNT/b-catenin signaling in XX gonads. Accordingly, the absence of RSPO1/Rspo1 in XX humans and mice leads to testicular differentiation and female-to-male sex...
Uploaded on: December 4, 2022 -
2004 (v1)Journal article
Sex determination in mammals directs an initially bipotential gonad to differentiate into either a testis or an ovary. This decision is triggered by the expression of the sex-determining gene Sry, which leads to the activation of male-specific genes including the HMG-box containing gene Sox9. From transgenic studies in mice it is clear that...
Uploaded on: December 3, 2022 -
July 21, 2018 (v1)Journal article
Testis differentiation requires high levels of proliferation of progenitor cells that give rise to two cell lineages forming the testis, the Sertoli and the Leydig cells. Hence defective cell cycling leads to testicular dysgenesis that has profound effects on androgen production and fertility. The growth factor NRG1 has been implicated in adult...
Uploaded on: February 22, 2023 -
July 21, 2018 (v1)Journal article
Testis differentiation requires high levels of proliferation of progenitor cells that give rise to two cell lineages forming the testis, the Sertoli and the Leydig cells. Hence defective cell cycling leads to testicular dysgenesis that has profound effects on androgen production and fertility. The growth factor NRG1 has been implicated in adult...
Uploaded on: December 3, 2022 -
May 2008 (v1)Journal article
The sex of an individual is determined by the fate of the gonad. While the expression of Sry and Sox9 is sufficient to induce male development, we here show that female differentiation requires activation of the canonical b-catenin signaling pathway. b-catenin activation is controlled by Rspo1 in XX gonads and Rspo1 knockout mice show...
Uploaded on: December 3, 2022 -
December 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022