Towards the assessment of myelination using time-dependent diffusion MRI indices

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Synopsis We study the sensitivity of time-dependent diffusion MRI indices or qτ-indices to demyelination in the mouse brain. For this, we acquire in vivo four-dimentional diffusion-weighted images-varying over gradient strength, direction and diffusion time-and estimate the qτ-indices from the corpus callosum. First order Taylor approximation of each index gives fitting coefficients α and β whose variance we investigate. Results indicate that, cuprizone intoxication affects mainly index coefficient β by introducing inequality of variances between the two mice groups, most significantly in the splenium and that MSD increases and RTOP decreases over diffusion time τ.

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