Published 2022 | Version v1
Publication Metadata-only

Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022

Coppi M.
Antonelli A.
Niccolai C.
Bartolini A.
Bartolini L.
Grazzini M.
Mantengoli E.
Farese A.
Pieralli F.
Mechi M. T.
Di Pilato V.
Giani T.
Rossolini G. M.
Others:
Coppi, M.
Antonelli, A.
Niccolai, C.
Bartolini, A.
Bartolini, L.
Grazzini, M.
Mantengoli, E.
Farese, A.
Pieralli, F.
Mechi, M. T.
Di Pilato, V.
Giani, T.
Rossolini, G. M.

Description

A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021-June 2022 in Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of NDM-Kp from cases observed in January 2021-June 2022 revealed that 21/52 were FDC-resistant. The outbreak was mostly sustained by clonal expansion of a mutant with inactivated cirA siderophore receptor gene, which exhibited high-level resistance to FDC (MIC ≥ 32 mg/L) and spread independently of FDC exposure.

Additional details

Identifiers Origin repository
Created:
February 14, 2024
Modified:
February 14, 2024