Clinical features and outcomes of bloodstream infections caused by New Delhi metallo-β-lactamase-producing enterobacterales during a regional outbreak

Creators: Falcone M.; Tiseo G.; Antonelli A.; Giordano C.; Di Pilato V.; Bertolucci P.; Parisio E. M.; Leonildi A.; Aiezza N.; Baccani I.; Tagliaferri E.; Righi L.; Forni S.; Sani S.; Mechi M. T.; Pieralli F.; Barnini S.; Rossolini G. M.; Menichetti F.

Others:: Falcone, M.; Tiseo, G.; Antonelli, A.; Giordano, C.; Di Pilato, V.; Bertolucci, P.; Parisio, E. M.; Leonildi, A.; Aiezza, N.; Baccani, I.; Tagliaferri, E.; Righi, L.; Forni, S.; Sani, S.; Mechi, M. T.; Pieralli, F.; Barnini, S.; Rossolini, G. M.; Menichetti, F.

Description

Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.

Clinical features and outcomes of bloodstream infections caused by New Delhi metallo-β-lactamase-producing enterobacterales during a regional outbreak

Description

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