Published February 8, 2019
| Version v1
Publication
BRCA1 Accelerates CtIP-Mediated DNA-End Resection
Description
DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-protein interactions, including cell-cycle-controlled interaction with BRCA1. The role of BRCA1 in DNA-end resection is not clear. Here, we develop an assay to study DNA resection in higher eukaryotes at high resolution. We demonstrate that the BRCA1-CtIP interaction, albeit not essential for resection, modulates the speed at which this process takes place.
Additional details
- URL
- https://idus.us.es/handle//11441/82770
- URN
- urn:oai:idus.us.es:11441/82770
- Origin repository
- USE