International consensus for a definition of disease flare in lupus
- Creators
- Ruperto N.
- Hanrahan L. M.
- Alarcon G. S.
- Belmont H. M.
- Brey R. L.
- Brunetta P.
- Buyon J. P.
- Costner M. I.
- Cronin M. E.
- Dooley M. A.
- Filocamo G.
- Fiorentino D.
- Fortin P. R.
- Franks A. G.
- Gilkeson G.
- Ginzler E.
- Gordon C.
- Grossman J.
- Hahn B.
- Isenberg D. A.
- Kalunian K. C.
- Petri M.
- Sammaritano L.
- Sanchez-Guerrero J.
- Sontheimer R. D.
- Strand V.
- Urowitz M.
- Von Feldt J. M.
- Werth V. P.
- Merrill J. T.
- Others:
- Ruperto, N.
- Hanrahan, L. M.
- Alarcon, G. S.
- Belmont, H. M.
- Brey, R. L.
- Brunetta, P.
- Buyon, J. P.
- Costner, M. I.
- Cronin, M. E.
- Dooley, M. A.
- Filocamo, G.
- Fiorentino, D.
- Fortin, P. R.
- Franks, A. G.
- Gilkeson, G.
- Ginzler, E.
- Gordon, C.
- Grossman, J.
- Hahn, B.
- Isenberg, D. A.
- Kalunian, K. C.
- Petri, M.
- Sammaritano, L.
- Sanchez-Guerrero, J.
- Sontheimer, R. D.
- Strand, V.
- Urowitz, M.
- Von Feldt, J. M.
- Werth, V. P.
- Merrill, J. T.
Description
The Lupus Foundation of America (LFA) convened an international working group to obtain a consensus definition of disease flare in lupus. With help from the Paediatric Rheumatology International Trials Organization (PRINTO), two web-based Delphi surveys of physicians were conducted. Subsequently, the LFA held a second consensus conference followed by a third Delphi survey to reach a community-wide agreement for flare definition. Sixty-nine of the 120 (57.5%) polled physicians responded to the first survey. Fifty-nine of the responses were available to draft 12 preliminary statements, which were circulated in the second survey. Eighty-seven of 118 (74%) physicians completed the second survey, with an agreement of 70% for 9/12 (75%) statements. During the second conference, three alternative flare definitions were consolidated and sent back to the international community. One hundred and sixteen of 146 (79.5%) responded, with agreement by 71/116 (61%) for the following definition: "A flare is a measurable increase in disease activity in one or more organ systems involving new or worse clinical signs and symptoms and/or laboratory measurements. It must be considered clinically significant by the assessor and usually there would be at least consideration of a change or an increase in treatment." The LFA proposes this definition for lupus flare on the basis of its high face validity. © The Author(s), 2011.
Additional details
- URL
- http://hdl.handle.net/11567/965738
- URN
- urn:oai:iris.unige.it:11567/965738
- Origin repository
- UNIGE