Periodic Forcing of Inhibition-Stabilized Networks: Nonlinear Resonances and Phase-Amplitude Coupling

Description

Inhibition stabilized networks (ISNs) are neural architectures with strong positive feedback among pyramidal neurons balanced by strong negative feedback from in-hibitory interneurons, a circuit element found in the hippocampus and the primary vi-sual cortex. In their working regime, ISNs produce damped oscillations in the γ-range in response to inputs to the inhibitory population. In order to understand the proper-ties of interconnected ISNs, we investigated periodic forcing of ISNs. We show that ISNs can be excited over a range of frequencies and derive properties of the resonance peaks. In particular, we studied the phase-locked solutions, the torus solutions and the resonance peaks. More particular, periodically forced ISNs respond with (possibly multi-stable) phase-locked activity whereas networks with sustained intrinsic oscilla-tions respond more dynamically to periodic inputs with tori. Hence, the dynamics are surprisingly rich and phase effects alone do not adequately describe the network re-sponse. This strengthens the importance of phase-amplitude coupling as opposed to phase-phase coupling in providing multiple frequencies for multiplexing and routing information. You can use \terry{text to print}essai

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