Published 2022
| Version v1
Journal article
Targeted Therapy for Older Patients with Non-Small Cell Lung Cancer: Systematic Review and Guidelines from the French Society of Geriatric Oncology (SoFOG) and the French-Language Society of Pulmonology (SPLF)/ French-Language Oncology Group (GOLF)
Creators
- Greillier, Laurent
- Gauvrit, Manon
- Paillaud, Éléna
- Girard, Nicolas
- Montégut, Coline
- Boulahssass, Rabia
- Wislez, Marie
- Pamoukdjian, Frédéric
- Corre, Romain
- Cabart, Mathilde
- Caillet, Philippe
- Belaroussi, Yaniss
- Frasca, Matthieu
- Noize, Pernelle
- Wang, Pascal
- Mebarki, Soraya
- Mathoulin-Pelissier, Simone
- Couderc, Anne Laure
Contributors
Others:
- Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique (COMPO) ; Centre Inria d'Université Côte d'Azur (CRISAM) ; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Cancérologie de Marseille (CRCM) ; Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC) ; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC) ; Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Institut Bergonié [Bordeaux] ; UNICANCER
- Cancer Research and Personalized Medicine - CARPEM [Paris] (SIRIC CARPEM) ; Hôpital Européen Georges Pompidou [APHP] (HEGP) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpital Cochin [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Necker - Enfants Malades [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut national du cancer (INCa)
- IMRB - CEPIA/"Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health" [Créteil] (U955 Inserm - UPEC) ; Institut Mondor de Recherche Biomédicale (IMRB) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)
- UFR Sciences de la santé Simone Veil (UVSQ Santé) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay
- Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)
- Hôpital Cochin [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Hôpital Avicenne [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Bordeaux population health (BPH) ; Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Aix Marseille Université (AMU)
- Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES) ; Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS)
- Institut National de la Santé et de la Recherche Médicale, Inserm: CIC1401; Institut Bergonié; Société de Pneumologie de Langue Française, SPLF
- We thank the review group: Fabrice Barlesi (French-language Society of Pul-monology (SPLF)/French-language Oncology Group (GOLF)), Claire Falandry (French Society of Geriatric Oncology (SoFOG)), Maxime Frelaut (French Society of Geriatric Oncology (SoFOG)) and Elisabeth Quoix (French-language Society of Pulmonology (SPLF)/French-language Oncology Group (GOLF)). We thank Caroline Lalet and Arthur Cohen (Inserm CIC1401, Institut Bergoni?, Clinical Research Plateform for older patients with cancer (PACAN)) for their support building search algorithms. We thank Emilie Nouguerede (Internal Medicine, Geriatrics and Therapeutic Unit, AP-HM, Marseille, France) for their support in the formatting of the manuscript.
Description
Systematic molecular profiling and targeted therapy (TKI) have changed the face of Non-Small Cell Lung Cancer (NSCLC) treatment. However, there are no specific recommendations to address the prescription of TKI for older patients. A multidisciplinary task force from the French Society of Geriatric Oncology (SoFOG) and the French Society of Pulmonology/Oncology Group (SPLF/GOLF) conducted a systematic review from May 2010 to May 2021. Protocol registered in Prospero under number CRD42021224103. Three key questions were selected for older patients with NSCLC: (1) to whom TKI can be proposed, (2) for whom monotherapy should be favored, and (3) to whom a combination of TKI can be proposed. Among the 534 references isolated, 52 were included for the guidelines. The expert panel analysis concluded: (1) osimertinib 80 mg/day is recommended as a first-line treatment for older patients with the EGFR mutation; (2) full-dose first generation TKI, such as erlotinib or gefitinib, is feasible; (3) ALK and ROS1 rearrangement studies including older patients were too scarce to conclude on any definitive recommendations; and (4) given the actual data, TKI should be prescribed as monotherapy. Malnutrition, functional decline, and the number of comorbidities should be assessed primarily before TKI initiation.
Abstract
International audienceAdditional details
Identifiers
- URL
- https://hal.science/hal-03579482
- URN
- urn:oai:HAL:hal-03579482v1
Origin repository
- Origin repository
- UNICA