Rab4b Is a Small GTPase Involved in the Control of the Glucose Transporter GLUT4 Localization in Adipocyte

Creators: Kaddai, Vincent; Gonzalez, Teresa; Keslair, Frédérique; Grémeaux, Thierry; Bonnafous, Stéphanie; Gugenheim, Jean; Tran, Albert; Gual, Philippe; Le Marchand-Brustel, Yannick; Cormont, Mireille

Others:: Signalisation moléculaire et obésité ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM); Nutrition, obésité et risque thrombotique (NORT) ; Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM); Institute of Developmental Biology and Cancer (IBDC) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA); Laboratory of Solid Tumors Genetics ; Nice University Hospital; Pôle Digestif ; Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet; Centre méditérannéen de médecine moléculaire (C3M) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service de Chirurgie Digestive / Centre de Transplantation Hépatique [CHU Nice] ; Centre Hospitalier Universitaire de Nice (CHU Nice); Centre méditerranéen de médecine moléculaire (C3M) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA); Université Côte d'Azur, Inserm, Centre Méditerranéen de Médecine Moléculaire (C3M), Team "Cellular and Molecular Pathophysiology of Obesity and Diabetes"

Description

Endosomal small GTPases of the Rab family, among them Rab4a, play an essential role in the control of the glucose transporter GLUT4 trafficking, which is essential for insulin-mediated glucose uptake. We found that adipocytes also expressed Rab4b and we observed a consistent decrease in the expression of Rab4b mRNA in human and mice adipose tissue in obese diabetic states. These results led us to study this poorly characterized Rab member and its potential role in glucose transport.

Abstract

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Rab4b Is a Small GTPase Involved in the Control of the Glucose Transporter GLUT4 Localization in Adipocyte

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Abstract

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