MDM2 gene amplification as selection tool for innovative targeted approaches in PD-L1 positive or negative muscle-invasive urothelial bladder carcinoma

Creators: Brunelli, Matteo; Tafuri, Alessandro; Cima, Luca; Cerruto, Maria Angela; Milella, Michele; Zivi, Andrea; Buti, Sebastiano; Bersanelli, Melissa; Fornarini, Giuseppe; Vellone, Valerio Gaetano; Rebuzzi, Sara Elena; Procopio, Giuseppe; Verzoni, Elena; Bracarda, Sergio; Sabbatini, Roberto; Baldessari, Cinzia; Eccher, Albino; Passalacqua, Rodolfo; Perrucci, Bruno; Giganti, Maria Olga; Donini, Maddalena; Panni, Stefano; Tucci, Marcello; Prati, Veronica; Ortega, Cinzia; Caliò, Anna; Alongi, Filippo; Munari, Enrico; Pappagallo, Giovanni; Iacovelli, Roberto; Mosca, Alessandra; Porta, Camillo; Martignoni, Guido; Antonelli, Alessandro

Others:: Brunelli, Matteo; Tafuri, Alessandro; Cima, Luca; Cerruto, Maria Angela; Milella, Michele; Zivi, Andrea; Buti, Sebastiano; Bersanelli, Melissa; Fornarini, Giuseppe; Vellone, Valerio Gaetano; Rebuzzi, Sara Elena; Procopio, Giuseppe; Verzoni, Elena; Bracarda, Sergio; Sabbatini, Roberto; Baldessari, Cinzia; Eccher, Albino; Passalacqua, Rodolfo; Perrucci, Bruno; Giganti, Maria Olga; Donini, Maddalena; Panni, Stefano; Tucci, Marcello; Prati, Veronica; Ortega, Cinzia; Caliò, Anna; Alongi, Filippo; Munari, Enrico; Pappagallo, Giovanni; Iacovelli, Roberto; Mosca, Alessandra; Porta, Camillo; Martignoni, Guido; Antonelli, Alessandro

Description

According to The Cancer Genome Atlas (TCGA), around 9% of bladder carcinomas usually show abnormalities of the murine double minute 2 (MDM2) gene, but a few studies have been investigated them. We profiled MDM2 gene amplification in a series of urothelial carcinomas (UC) considering the molecular subtypes and expression of programmed death ligand 1 (PD-L1).

MDM2 gene amplification as selection tool for innovative targeted approaches in PD-L1 positive or negative muscle-invasive urothelial bladder carcinoma

Description

Additional details