Published June 26, 2023
| Version v1
Publication
Ingestion of Bacillus cereus spores dampens the immune response to favor bacterial persistence
Contributors
Others:
- Institut Sophia Agrobiotech (ISA) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE)-Université Côte d'Azur (UCA)
- Centre méditerranéen de médecine moléculaire (C3M) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)
- Laboratoire de sécurité des aliments de Maisons-Alfort (LSAl) ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)
Description
Members of the Bacillus cereus group are spore-forming bacteria commonly associated with foodborne outbreaks. The capacity of these bacteria to form highly resistant dormant entities, called spores, enables them to survive under extreme conditions. Bacillus thuringiensis (Bt) belongs to the group of B. cereus. Thanks to the toxins (named Cry) Bt produces during sporulation, Bt spores are the most used microbial insecticide to specifically kill lepidopteran larvae, a major pest crop. Here, we were interested in the fate and behavior of Bt and Bc in the intestine of Drosophila and mice (two organisms not targeted by Bt Cry toxins) upon ingestion of spores, as well as the innate immune responses mounted by the host.
Abstract
International audienceAdditional details
Identifiers
- URL
- https://hal.science/hal-04260235
- URN
- urn:oai:HAL:hal-04260235v1
Origin repository
- Origin repository
- UNICA