Intercellular mitochondria trafficking highlighting the dual role of mesenchymal stem cells as both sensors and rescuers of tissue injury
- Others:
- Institut Mondor de Recherche Biomédicale (IMRB) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)
- Institut de Génétique Moléculaire de Montpellier (IGMM) ; Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
- Centre méditerranéen de médecine moléculaire (C3M) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)
- Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) ; Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
- We thank the Montpellier RIO imaging facility (MRI) for providing adequate environment for confocal microscopy. AMR and M.L.V are staff scientists from the French National Institute of Health and Medical Research (INSERM) and the National Center for scientific research (CNRS), respectively. J.N. is supported by a PhD fellowship from the French Ministry of Research. This work was supported by grants from the Ligue Contre le Cancer-Comité de l'Aude and Association pour la Recherche et l'Etude des Maladies Cardiovasculaires (AREMCAR).
Description
Mitochondria are crucial organelles that not only regulate the energy metabolism, but also the survival and fate of eukaryotic cells. Mitochondria were recently discovered to be able to translocate from one cell to the other. This phenomenon was observed in vitro and in vivo, both in physiological and pathophysiological conditions including tissue injury and cancer. Mitochondria trafficking was found to exert prominent biological functions. In particular, several studies pointed out that this process governs some of the therapeutic effects of mesenchymal stem cells (MSCs). In this review, we give an overview of the current knowledge on MSC-dependent intercellular mitochondria trafficking and further discuss the recent findings on the intercellular mitochondria transfer between differentiated and mesenchymal stem cells, their biological significance and the mechanisms underlying this process.
Abstract
International audience
Additional details
- URL
- https://www.hal.inserm.fr/inserm-01855876
- URN
- urn:oai:HAL:inserm-01855876v1
- Origin repository
- UNICA