Nepheliosyne B, a new polyacetylenic acid from the new caledonian marine sponge Niphates sp.

Creators: Legrave, Nathalie; Hamrouni-Buonomo, Souhir; Dufies, Maeva; Guérineau, Vincent; Vacelet, Jean; Auberger, Patrick; Amade, Philippe; Mehiri, Mohamed

Others:: Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA); Institut de Chimie des Substances Naturelles (ICSN) ; Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Description

A new C47 polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.

Abstract

International audience

Nepheliosyne B, a new polyacetylenic acid from the new caledonian marine sponge Niphates sp.

Description

Abstract

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