Published 2020 | Version v1
Publication

Synthesis of polyoxygenated heterocycles by diastereoselective functionalization of a bio-based chiral aldehyde exploiting the Passerini reaction

Citation

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Description

A chiral bio-based building block, prepared by the lipase-mediated desymmetrization of an erythritol derivative, was further functionalized and then submitted to stereoselective Passerini reactions, allowing the synthesis of a small library of new molecules. Thanks to the presence of different functional groups, further cyclizations were performed providing bicyclic polyoxygenated heterocycles.

Additional details

Created:
April 14, 2023
Modified:
November 30, 2023