Prognostic value of SARS-CoV-2 on patients undergoing cardiac surgery
- Creators
- Bonalumi G.
- Pilozzi Casado A.
- Barbone A.
- Garatti A.
- Colli A.
- Giambuzzi I.
- Torracca L.
- Ravenni G.
- Folesani G.
- Murara G.
- Pantaleo A.
- Piciche M.
- Villa E.
- Ferraro F.
- Vendramin I.
- Livi U.
- Montalto A.
- Musumeci F.
- Tarzia V.
- Trumello C.
- De Bonis M.
- Margari V.
- Paparella D.
- Salsano A.
- Santini F.
- Nicolardi S.
- Patane F.
- Mammana L.
- Cura Stura E.
- Rinaldi M.
- Massi F.
- Triggiani M.
- Grazioli V.
- Giroletti L.
- Rubino A.
- De Feo M.
- Audo A.
- Regesta T.
- Barili F.
- Gerosa G.
- Di Mauro M.
- Parolari A.
- Others:
- Bonalumi, G.
- Pilozzi Casado, A.
- Barbone, A.
- Garatti, A.
- Colli, A.
- Giambuzzi, I.
- Torracca, L.
- Ravenni, G.
- Folesani, G.
- Murara, G.
- Pantaleo, A.
- Piciche, M.
- Villa, E.
- Ferraro, F.
- Vendramin, I.
- Livi, U.
- Montalto, A.
- Musumeci, F.
- Tarzia, V.
- Trumello, C.
- De Bonis, M.
- Margari, V.
- Paparella, D.
- Salsano, A.
- Santini, F.
- Nicolardi, S.
- Patane, F.
- Mammana, L.
- Cura Stura, E.
- Rinaldi, M.
- Massi, F.
- Triggiani, M.
- Grazioli, V.
- Giroletti, L.
- Rubino, A.
- De Feo, M.
- Audo, A.
- Regesta, T.
- Barili, F.
- Gerosa, G.
- Di Mauro, M.
- Parolari, A.
Description
Objective: To analyze Italian Cardiac Surgery experience during the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) identifying risk factors for overall mortality according to coronavirus disease 2019 (COVID-19) status. Methods: From February 20 to May 31, 2020, 1354 consecutive adult patients underwent cardiac surgery at 22 Italian Centers; 589 (43.5%), patients came from the red zone. Based on COVID-19 status, 1306 (96.5%) were negative to SARS-CoV-2 (COVID-N), and 48 (3.5%) were positive to SARS-CoV-2 (COVID-P); among the COVID-P 11 (22.9%) and 37 (77.1%) become positive, before and after surgery, respectively. Surgical procedures were as follows: 396 (29.2%) isolated coronary artery bypass grafting (CABG), 714 (52.7%) isolated non-CABG procedures, 207 (15.3%) two associate procedures, and three or more procedures in 37 (2.7%). Heart failure was significantly predominant in group COVID-N (10.4% vs. 2.5%, p =.01). Results: Overall in-hospital mortality was 1.6% (22 cases), being significantly higher in COVID-P group (10 cases, 20.8% vs. 12, 0.9%, p <.001). Multivariable analysis identified COVID-P condition as a predictor of in-hospital mortality together with emergency status. In the COVID-P subgroup, the multivariable analysis identified increasing age and low oxygen saturation at admission as risk factors for in-hospital mortality. Conclusion: As expected, SARS-CoV-2 infection, either before or soon after cardiac surgery significantly increases in-hospital mortality. Moreover, among COVID-19-positive patients, older age and poor oxygenation upon admission seem to be associated with worse outcomes.
Additional details
- URL
- http://hdl.handle.net/11567/1073931
- URN
- urn:oai:iris.unige.it:11567/1073931
- Origin repository
- UNIGE