CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.
- Others:
- Système des phagocytes mononucléés et immunopathologie ; Université Paris Descartes - Paris 5 (UPD5)
- Immunologie des maladies infectieuses allergiques et autoimmunes ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Centre for Cellular and Molecular Biology of Inflammation ; King's College London
- Gladstone Institute of Cardiovascular Disease ; University of California [San Francisco] (UC San Francisco) ; University of California (UC)-University of California (UC)
- Centre d'étude et de recherche thérapeutiques en ophtalmologie ; Université Paris Descartes - Paris 5 (UPD5)
- The Roslin Institute and Royal (Dick) School of Veterinary Studies ; University of Edinburgh
- Développement des Lymphocytes ; Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)
- This work was supported by an European Young Investigator (EURYI) award to F. Geissmann, grants from Institut National de la Sant é et de la Recherche M é dicale (Avenir) and Human Frontier Science Program (CDA) to G. Lauvau, grants from the Agence Nationale de la Recherche (ANR IRAP2005) to F. Geissmann and G. Lauvau, and grants from the Fondation pour la Recherche Medicale to F. Geissmann (Equipe FRM 2006) and to G. Lauvau (FRM equipments fund).
Description
CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with other DC precursors and the role of CX(3)CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1(+) inflammatory monocytes that differentiate into TipDCs during infection. CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.
Abstract
International audience
Additional details
- URL
- https://hal-pasteur.archives-ouvertes.fr/pasteur-00428989
- URN
- urn:oai:HAL:pasteur-00428989v1
- Origin repository
- UNICA