Intestinal Ioidide Secretion and its Dependence Upon Mucosal I Permeability
Description
Iodide secretion across different regions of rat small inlestine ha.s been investigated in vitro using the standard Wilson- Wisema technique. Net I secretion was observed along the entire small intestine, being significantly higher in the central region. Anaerobic conditions, ouabain {2 mM) and Na• free Ringer solution prevented net I· secretion, whilts, both theophyilline (1 mM) and carbachol {0,1 mM) enhanced the observed basal intestinal I· secretion. Furthermore, Caº'-deprived bathing solutions significantly reduced intestinal 1- secretion. Epithelial 1- uptake from both mucosa) and serosa) sides was measured by using a Ussing-type chamber technique. The initial rate of I·-uptake across the mucosal membrane was significantly higher in the central region than in the proximal part of rat small intestine. No significant differences were observed in the rate of I·-uptake from the serosa) side. These studies suggest that mucosa! 1- permeability might determine the direction of net 1- intestinal transport and that cytosolic Caº+ may be a physiological regulator of intestinal 1- transport.
Additional details
- URL
- https://idus.us.es/handle/11441/32460
- URN
- urn:oai:idus.us.es:11441/32460
- Origin repository
- USE