Published 2023 | Version v1
Publication Metadata-only

A practical approach for PD-L1 evaluation in gastroesophageal cancer

Angerilli V.
Fassan M.
Parente P.
Gullo I.
Campora M.
Rossi C.
Sacramento M. L.
Pennelli G.
Vanoli A.
Grillo F.
Mastracci L.
Others:
Angerilli, V.
Fassan, M.
Parente, P.
Gullo, I.
Campora, M.
Rossi, C.
Sacramento, M. L.
Pennelli, G.
Vanoli, A.
Grillo, F.
Mastracci, L.

Description

PD-L1 is an established predictive immunohistochemical biomarker of response to immune checkpoint inhibitors. At present, PD-L1 is routinely assessed on biopsy samples of advanced gastroesophageal cancer patients before initiating first-line treatment. However, PD-L1 is still a suboptimal biomarker, due to changing cut-off values and scoring systems, interobserver and interlaboratory variability. This practical illustrated review discusses the range of staining patterns of PD-L1 and the potential pitfalls and challenges that can be encountered when evaluating PD-L1, focusing on gastric and gastroesophageal adenocarcinoma (G/GEA) and esophageal squamous cell carcinoma (ESCC).

Additional details

Identifiers Origin repository
Created:
February 4, 2024
Modified:
February 4, 2024