Phosphinite Thioglycosides Derived from Natural D-Sugars as Useful P/S Ligands for the Synthesis of Both Enantiomers in Palladium-Catalyzed Asymmetric Substitution

Description

Phosphinite thioglycosides I for which a modular synthetic approach is reported, were found highly efficient catalyst precursors for palladium(0)-catalyzed asymmetric substitution. Both enantiomers of the allylated products have been obtained with high ee (up to 96%) using natural sugars as catalyst precursors.

Abstract

Dirección General de Investigación Científica y Técnica PB BQU2003-00937 y CTQ2004-01057

Abstract

Fundación Ramón Areces

Additional details